PAGES: 392-394 DOI: 10.1590/0074-0276108032013021 Short communication
Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

Camila Marx1, Tatiana Schäffer Gregianini2, Fernanda Kieling Moreira Lehmann1, Vagner Ricardo Lunge1,3, Silvia de Carli1, Bibiana Paula Dambrós2, Gabriela Luchiari Tumioto2, Claudete Seadi2, André Salvador Kazantzi Fonseca3 , Nilo Ikuta1,3,+

1Universidade Luterana do Brasil, Canoas, RS, Brasil
2Laboratório Central de Saúde Pública do Rio Grande do Sul, Porto Alegre, RS, Brasil
3Simbios Biotecnologia, Cachoeirinha, RS, Brasil


The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

Received 30 May 2012
Accepted 14 September 2012
Financial support: FAPERGS (09/0570-6)
+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.


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