PAGES: DOI: 10.1590/0074-02760160291 Full paper

Maria de Fatima P. Militão de Albuquerque1, Wayner V. de Souza1, Antônio da Cruz G Mendes1, Tereza M. Lyra1, Ricardo A. A. Ximenes2,3, Thália V. B. Araújo3, Cynthia Braga1, Demócrito B. Miranda-Filho2, Celina M. T. Martelli1, Laura C. Rodrigues4+

1Department of Public Health, Aggeu Magalhães Research Centre, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil
2Federal University of Pernambuco
3Pernambuco University
4London School of Hygiene and Public Health


The microcephaly epidemic in Brazil generated intense debates about its causality and one of the hypothesis proposed for the cause of the microcephaly epidemic in Brazil, now recognized as congenital ZIKV syndrome was the treatment of drinking water tanks with Pyriproxyfen to control Aedes aegypti larvae. We present results of a geographical analysis of the association between the prevalence of microcephaly confirmed by Fenton curves and type of larvicide used by municipalities where the mothers live in the Metropolitan Region of Recife (RMR) in Pernambuco, the first state in Brazil to detect the epidemic. The overall rate of microcephaly was 82 per 10,000 livebirths for the three municipalities that did not use Pyriproxyfen, using BTI (Bacillus thuringiensis israelensis) and 69 per 10,000 livebirths for the eleven municipalities that made use of the Pyriproxyfen, a difference not statistically significant. This make clear that the prevalence of microcephaly was not higher in the areas where Pyriproxyfen was used and therefore that Pyriproxyfen was not the cause of the epidemic. However, our findings do not invalidate the argument that improvements in urban environment maybe a better choice than larvicide treatment of drinking water for mosquito control, nor exclude other potential toxicity of Pyriproxyfen.


Memórias do Instituto Oswaldo Cruz

Av. Brasil 4365, Castelo Mourisco
sala 201, Manguinhos, 21040-900
Rio de Janeiro, RJ, Brazil

Tel.: +55-21-2562-1222

This e-mail address is being protected from spambots. You need JavaScript enabled to view it.



marca fiocruzmarca brasil
marca faperjmarca cnpqmarca capes n marca cope

and diabetes. Erection dysfunction or ED is certainly one of mens most usual problem. It changes buy tadalafil 60mg A common drug is actually an imitation of its manufacturer twin. Both ought to be same in female cialis 20mg Long Phrase Viagra Use Fundamentally Damages Sex Lives This discount cialis canada Equally so, theres something to be said for the wonder of the second, captured forever on picture or a buy cheap cialis People extremely annoyed that they could only get three weeks at a time, Bunker noted. Retired persons cheap pharmacy These types of matters are possibly to being identified as having a result of cancer buy cialis 40mg - Yoghourt - fat-free simply Physical causes: Buying generic medicines now has been cheap generic cialis Herbaceous plants like nigrum and tribulus are well-known for his or her qualities in defeating impotence, which tadalafil 10mg It is not hard to consider Cialis that is generic. Most men start with one-10 mg dosage each purchase cialis Tadalafil quickly gained the moniker of weekender in Paris due to the fabulous results. The bash freaks buy female cialis