MEM INST OSWALDO CRUZ, RIO DE JANEIRO, Vol. 112 | 2017
PAGES: DOI: 10.1590/0074-02760170307 Short communication
Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C

Adele Caterino-de-Araujo1+, Fabiana Aparecida Alves1, Karoline Rodrigues Campos1, Marcílio Figueiredo Lemos2, Regina Célia Moreira2

1Secretaria de Estado da Saúde de São Paulo, Coordenadoria de Controle de Doenças, Instituto Adolfo Lutz, Centro de Imunologia, Laboratório de Pesquisa em HTLV, São Paulo, SP, Brasil
2Secretaria de Estado da Saúde de São Paulo, Coordenadoria de Controle de Doenças, Instituto Adolfo Lutz, Centro de Virologia, Núcleo de Doenças de Transmissão Sanguínea e Sexual, Laboratório de Hepatites, São Paulo, SP, Brasil

Abstract

With this study, the authors hope to alert clinicians regarding the presence of human T-cell lymphotropic virus type 1 and 2 (HTLV-1/-2) infections in patients with viral hepatitis B and C in Brazil. HTLV-1/-2 were detected in 1.3% of hepatitis B virus (HBV)- and 5.3% of hepatitis C virus (HCV)-infected blood samples sent for laboratory viral load measurements. A partial association of human immunodeficiency virus (HIV)-1 and HTLV-1/-2 infection was detected in patients with HCV (HIV+, 27.3%), whereas this association was almost 100% in HBV-infected patients (HIV+, all except one). The high prevalence of HTLV-1/-2 infection among patients with hepatitis C was of concern, as HTLV-1/-2 could change the natural course of subsequent liver disease. The authors suggest including HTLV-1/-2 serology in the battery of tests used when following patients with viral hepatitis in Brazil, regardless of the HIV status.

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Financial support: FAPESP (# 2012/51220-8),
CNPq PD (# 302661/2015-8), CAPES.
ACA was supported by CNPq PD; FAA and KRC respectively hold master’s and doctoral fellowships supported by CAPES.
+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it. / This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 31 July 2017
Accepted 6 October 2017

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