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MEM INST OSWALDO CRUZ, RIO DE JANEIRO, 113(2) February 2018
PAGES: 135-136 DOI: 10.1590/0074-02760170347 Short communication
Single shot of 17D vaccine may not confer life-long protection against yellow fever

Pedro FC Vasconcelos+

Instituto Evandro Chagas, Ananindeua, PA, Brasil

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Abstract

The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus. Until 2013, the World Health Organization (WHO) recommended the administration of a vaccine dose every ten years. A new recommendation of a single vaccine dose to confer life-long protection against YFV infection has since been established. Recent evidence published elsewhere suggests that at least a second dose is needed to fully protect against YF disease. Here, we discuss the feasibility of administering multiple doses, the necessity for a new and modern vaccine, and recommend that the WHO conveys a meeting to discuss YFV vaccination strategies for people living in or travelling to endemic areas.

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Received 25 August 2017
Accepted 31 October 2017