MEM INST OSWALDO CRUZ, RIO DE JANEIRO, Vol. 112 | 2017
PAGES: DOI: 10.1590/0074-02760170391 Review
The war on cryptococcosis: A Review of the antifungal arsenal

Ahmad Mourad, John R Perfect+

Duke University Medical Center, Department of Medicine, Division of Infectious Diseases, Durham, NC, USA

Abstract

Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis remain very high. Unfortunately, despite several antifungal agents available for treatment, morbidity and mortality rates remain high with this fungal infection. In this Review, we will describe the treatments and strategies for success, identify the failures, and provide insights into the future developments / improvements for management. This sugar-coated yeast can play havoc within the human brain. Our goals must be to either prevent or diagnose disease early and treat aggressively with all our clinical tools when disease is detected.

+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 25 September 2017
Accepted 23 November 2017

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