PAGES: DOI: 10.1590/0074-02760170440 Full paper
Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease

Eduardo OV Curvo1, Roberto R Ferreira2, Fabiana S Madeira1, Gabriel F Alves1, Mayara C Chambela1, Veronica G Mendes1, Luiz Henrique C Sangenis1, Mariana C Waghabi2, Roberto M Saraiva1,+

1Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil
2Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil


BACKGROUND Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function.

OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease.

METHODS This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function.

FINDINGS TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction.

CONCLUSIONS TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.

Financial support: FAPERJ (E26/110.910/2013, E-26/110.176/2014, and E-26/201.561/2014), CNPq [305088/2013-0 (to RMS)].
+ Corresponding-author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 16 October 2017
Accepted 30 December 2017


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