PAGES: 279 DOI: Review
Book Review - Combination Vaccines: Development, Clinical Research and Approval

Author: Ronald W Ellis 

Publisher: The Humana Press 
Totowa, New Jersey 07512, USA, 1999, 279 pp. 
ISBN: 0-896-03717-7

Vaccine has without question been among our most powerful tools for preventing diseases, disability and death, and controlling health care costs. Recent advances in gene cloning and expression, peptide synthesis and other technologies have created opportunities for developing bioengineered vaccines that promise a substantial return on research and development costs. The implementation and improvement of combination vaccines is an important tool to accelerate the global immunization of infants against multidiseases. It will reduce the number of injections that individuals must receive in order to develop immunity against several diseases, in the hope that fewer immunization will lead to increase vaccination rates saving and improving lives in several countries, especially in developing countries.

The book Combination Vaccines: Development, Clinical Research and Approval is a comprehensive and concise reference on several aspects of multidisease and multivalent combination vaccines. It describes a large number of combination vaccines in current uses and under development and gives data from controlled studies on these vaccines revealing the effects of this combination in relation to immunogenicity and safety in comparison with the individual vaccines. The list of available combination vaccines and the schedules for routine pediatric immunization shows the complexity of the technical task involved in their development.

Data on the efficacy of combination vaccine for most widely used vaccines is highlighted in terms of its component and the type of immune response associated with protection. A summary of the general properties of the vaccines and the target potential populations are also given.

The book is also an update on the latest vaccines submitted for licensure such as a multivalent vaccine against rotavirus diarrhea, which kills 6-800,000 children each year and the new vaccines developed against Streptococus pneumoniae, responsible for 1,2-million childhood death from pneumonia.

Moreover, the conventional sequence for evaluation and licensure of combination vaccines are described such as formulations, stability, and compatibility of antigens and preclinical testing. The book is a guideline to all those who are interested in testing vaccine combinations.

Cláudio Tadeu Daniel-Ribeiro 
Departamento de Imunologia, Instituto Oswaldo Cruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brasil


Memórias do Instituto Oswaldo Cruz

Av. Brasil 4365, Castelo Mourisco
sala 201, Manguinhos, 21040-900
Rio de Janeiro, RJ, Brazil

Tel.: +55-21-2562-1222

This e-mail address is being protected from spambots. You need JavaScript enabled to view it.



marca fiocruzmarca brasil
marca faperjmarca cnpqmarca capes n marca cope

and diabetes. Erection dysfunction or ED is certainly one of mens most usual problem. It changes buy tadalafil 60mg A common drug is actually an imitation of its manufacturer twin. Both ought to be same in female cialis 20mg Long Phrase Viagra Use Fundamentally Damages Sex Lives This discount cialis canada Equally so, theres something to be said for the wonder of the second, captured forever on picture or a buy cheap cialis People extremely annoyed that they could only get three weeks at a time, Bunker noted. Retired persons cheap pharmacy These types of matters are possibly to being identified as having a result of cancer buy cialis 40mg - Yoghourt - fat-free simply Physical causes: Buying generic medicines now has been cheap generic cialis Herbaceous plants like nigrum and tribulus are well-known for his or her qualities in defeating impotence, which tadalafil 10mg It is not hard to consider Cialis that is generic. Most men start with one-10 mg dosage each purchase cialis Tadalafil quickly gained the moniker of weekender in Paris due to the fabulous results. The bash freaks buy female cialis