MEM INST OSWALDO CRUZ, RIO DE JANEIRO, 113(2) February 2018
PAGES: 126-129 DOI: 10.1590/0074-02760170119 Short communication
Comparative genomics of pathogenic Leptospira interrogans serovar Canicola isolated from swine and human in Brazil

Luisa Z Moreno1, Fabiana Miraglia2, Frederico S Kremer3, Marcus R Eslabao3, Odir A Dellagostin3, Walter Lilenbaum2, Julio C Freitas4, Silvio A Vasconcellos1, Marcos B Heinemann1, Andrea M Moreno1,+

1Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Laboratório de Epidemiologia Molecular e Resistência a Antimicrobianos, São Paulo, SP, Brasil
2Universidade Federal Fluminense, Departamento de Microbiologia e Parasitologia, Laboratório de Bacteriologia Veterinária, Niterói, RJ, Brasil
3Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS, Brasil
4Universidade Estadual de Londrina, Departamento de Medicina Veterinária Preventiva, Londrina, PR, Brasil

Abstract

Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health. Both human and porcine serovar Canicola isolates also presented sequences with high identity to the Chinese serovar Canicola published plasmids pGui1 and pGui2. The plasmids identification in the Brazilian and Chinese serovar Canicola strains suggest that extra-chromosomal elements are one more feature of this serovar that was previously unnoticed.

Financial support: CNPq, CAPES, FAPESP (2011/18290-0, 2013/17136-2).
+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 26 March 2017
Accepted 26 June 2017

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