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MEM INST OSWALDO CRUZ, RIO DE JANEIRO, Vol. 113 | 2018
PAGES: DOI: 10.1590/0074-02760170487 Review
RNA viruses in trypanosomatid parasites: a historical overview

Danyil Grybchuk1, Alexei Y Kostygov1, Diego H Macedo1, Claudia M d’Avila-Levy2, Vyacheslav Yurchenko1,+

1University of Ostrava, Faculty of Science, Life Science Research Centre, Ostrava, Czech Republic
2Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Estudos Integrados em Protozoologia, Coleção de Protozoários, Rio de Janeiro, RJ, Brasil

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Abstract

Viruses of trypanosomatids are now being extensively studied because of their diversity and the roles they play in flagellates’ biology. Among the most prominent examples are leishmaniaviruses implicated in pathogenesis of Leishmania parasites. Here, we present a historical overview of this field, starting with early reports of virus-like particles on electron microphotographs, and culminating in detailed molecular descriptions of viruses obtained using modern next generation sequencing-based techniques. Because of their diversity, different life cycle strategies and host specificity, we believe that trypanosomatids are a fertile ground for further explorations to better understand viral evolution, routes of transitions, and molecular mechanisms of adaptation to different hosts.

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Financial support: This work was supported by the Grant Agency of Czech Republic awards 16-18699S and 17-10656S to VY, CAPES, CNPq, FAPERJ, FIOCRUZ (to CMDL).
DG and DHM were funded by grants from the University of Ostrava.
+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 10 November 2017
Accepted 20 December 2017